Fetal brain genomic reprogramming following asphyctic preconditioning

Brain apoptosis and carotid artery reactivity in fetal asphyctic preconditioning.

We aimed to develop a model of fetal hypoxia-ischemia (HI) preconditioning that reflects the pathophysiological conditions of perinatal asphyxia more closely than the existing neonatal stroke models. Fetal asphyxia (FA) was induced by clamping the uterine vasculature on embryonic day E17. At birth (P0), severe perinatal asphyxia (SPA) was induced during cesarean section. At P4, carotid arteries...

Cardiac genomic response following preconditioning stimulus.

This review focuses on the genomic response following a preconditioning stimulus. Initial studies demonstrated that classical ischemic preconditioning mediated by cyclic episodes of short durations of reversible ischemia and reperfusion could result in the reprogramming of gene expression. Some of these genes are translated into proteins during the late preconditioning or so-called "second wind...

Role of morphine preconditioning and nitric oxide following brain ischemia reperfusion injury in mice

Objective(s): Morphine dependence (MD) potently protects heart against ischemia reperfusion (IR) injury through specific signaling mechanisms, which are different from the pathways involved in acute morphine treatment or classical preconditioning. Since opioid receptor density changes post cerebral ischemia strongly correlated with brain histological damage, in the present study, we tried to el...

Reprogramming the response to stroke by preconditioning.

role of morphine preconditioning and nitric oxide following brain ischemia reperfusion injury in mice

objective(s): morphine dependence (md) potently protects heart against ischemia reperfusion (ir) injury through specific signaling mechanisms, which are different from the pathways involved in acute morphine treatment or classical preconditioning. since opioid receptor density changes post cerebral ischemia strongly correlated with brain histological damage, in the present study, we tried to el...